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URL http://www.rockymountainbmt.com/news/A-new-study-quotB-1-B-cells-development-selection-natural-autoantibody-and-leukemiaquot-is-now-available-10637.html

A new study, "B-1 B cells: development, selection, natural autoantibody and leukemia," is now available

03-09-2007

According to recent research from the United States, "B-1 (CD5+) B cells constitute a phenotypic and functionally distinct population of B cells in mouse that show enriched expression of autoreactive B-cell antigen receptors and that produce several types of natural autoantibodies. Recently, there has been much progress in this field of research."

"Evidence has appeared for the existence of distinctive B-cell precursors that preferentially generate B-1 B cells, and the crucial requirement for strong B-cell antigen receptor signaling in the maturation of B-1 B cells has been established. Other work focuses on a phenotypically similar population that lacks CD5, termed 'B-1b', which shows similarities and differences from most CD5+ B cells in both development and function," wrote R.R Hardy and colleagues, Fox Chase Cancer Center, Division of Basic Science.

The researchers concluded: "The relationship of normal B-1 cells with B-cell lymphomas and leukemias continues to be a subject of interest and debate."

Hardy and colleagues published their study in Current Opinion In Immunology (B-1 B cells: development, selection, natural autoantibody and leukemia. Current Opinion In Immunology, 2006;18(5):547-55).

For additional information, contact R.R. Hardy, Fox Chase Cancer Center, Division of Basic Science, Philadelphia, PA 19111 USA.

This article was prepared by Surgery Litigation & Law Week editors from staff and other reports. Copyright 2007, Surgery Litigation & Law Week via NewsRx.com.