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Acute myeloid leukemia (AML) was associated with cyclin A1 expression

08-16-2006

According to recent research from Sweden, "A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of AML. Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL)."

"Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient age (p=.006), but not with cytogenetic abnormalities," explained C. Holm and colleagues, University of Lund Hospital.

The researchers concluded, "Patients with high levels of cyclin A1 had poorer event-free survival (57.9%) compared to patients with lower levels (75%)."

Holm and colleagues published their study in Leukemia Research (Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia. Leuk Res, 2006;30(3):254-261).

For additional information, contact J.L. Persson, University of Lund Hospital, Dept. Laboratory Med, Division Pathology, S-20502 Malmo, Sweden.

Keywords: Malmo, Sweden, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Cell Cycle, Cyclin Dependent Kinase, Patient Age, Disease Characteristics, Event Free Survival, Genetics, Oncology, Pediatric, Cyclin A1.

This article was prepared by Cancer Gene Therapy Week editors from staff and other reports. Copyright 2006, Cancer Gene Therapy Week via NewsRx.com.