Adult acute lymphoblastic leukemia patients with dic(7:9) demonstrate a consistent phenotype

09-27-2006

According to a recent report from Australia, "We report the case, of three adults with acute lymphoblastic leukemia (ALL) who had a dic(7;9)(p11.2;p11) on the diagnostic bone marrow cytogenetic analysis."

"All three were males with B-ALL (aged 25, 38, and 48 years) who at presentation had 90-100% replacement of marrow with lymphoblasts. One patient died 23 months post induction therapy, which was 9 months post allogeneic stem cell transplantation (SCT); as of writing," researchers said.

"The other two patients were in remission and well, one of them at 4 years after SCT and the other at 7.5 years without SCT," wrote A. Smith and colleagues at the Royal Alexandra Hospital for Children in Westmead.

"To our knowledge," concluded the authors, "these cases are the first reported in adult ALL with dic(7:9) and demonstrate a consistent phenotype, with good initial response to therapy but variable long-term outcome."

Smith and colleagues published their study in Cancer Genetics and Cytogenetics (Three adults with acute lymphoblastic leukemia and dic(7;9)(P11.2;p11). Cancer Genet Cytogenet, 2006;166(1):86-88).

For additional information, contact A. Smith, Royal Alexandra Hospital Children, Dept. Cytogenet, Locked Bag 4001, Westmead, NSW 2145, Australia.

Keywords: NSW, Australia, Adult Acute Lymphoblastic Leukemia, Cytogenetic Analysis, Stem Cell Transplantation, Long-Term Outcome, Response to Therapy.

This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2006, Clinical Oncology Week via NewsRx.com.