Childhood cancer survival prognostic factors identified

04-24-2006

Prognostic factors for survival from childhood cancer were identified.

"Survival after childhood cancer has been improving since the late 1970s in most developed countries. The Childhood Cancer Registry of Piedmont has been recording malignant tumors in children (0-14 years) throughout Piedmont since 1967," scientists in Italy reported.

"The present paper is based on the records of the 2,970 children diagnosed during the period 1970-2001; survival rates are estimated up to June 30, 2004. Based on records from the Registrar Offices of the relevant towns of residence, 1,698 children were reported to be alive, 1,252 deceased, and 20 were of unknown vital status," explained E. Dama and colleagues, S. Giovanni Hospital.

"Over the period 1970-2001, 5-year survival rates for all tumor types combined showed a statistically significant increasing trend (p<.0001). For acute lymphocytic leukemia, the survival rate increased steadily from 24.7% (95% CI 15.0-34.3) in 1970-1974 to 87.8% (82.1-93.6) in 1995-1999. Five-year survival rates for central nervous system tumors increased from 32.8% (21.0-44.6) in 1970-1974 to 80.3% (72.6-88.0) in 1990-1994 and decreased thereafter.

"Age of less than 1 year at time of diagnosis was a favorable prognostic factor for neuroblastoma and ganglioneuroblastoma. The extent of disease at diagnosis was related to prognosis for neuroblastoma and ganglioneuroblastoma and other selected solid tumors. A white blood cell count greater than 50,000x106 cells/l was associated with decreased survival in children with acute lymphocytic leukemia and acute non-lymphocytic leukemia," stated the investigators.

The researchers concluded, "We have found positive trends in survival for all tumor types in Piedmont, similar to those reported by other population-based cancer registries. Age, extent of disease, and white blood cell count at diagnosis are prognostic factors for selected cancer sites."

Dama and colleagues published their study in European Journal of Pediatrics (Time trends and prognostic factors for survival from childhood cancer: a report from the Childhood Cancer Registry of Piedmont (Italy). Eur J Pediatr, 2006;165(4):240-249).

For more information, contact C. Magnani, S. Giovanni Hospital, CeRMS, Cancer Epidemiology Unit CPO Piemonte, Childhood Cancer Registry Piedmont, V Santena 7, I-10126 Turin, Italy.

Publisher contact information for the European Journal of Pediatrics is: Springer, 233 Spring Street, New York, NY 10013, USA.

Keywords: Turin, Italy, Cancer Registries, Central Nervous System, Central Nervous System Injury, Childhood Cancer, Childhood Carcinoma, Childhood Neoplasm, Epidemiology, Ganglion, Leukemia, Neurology, Oncology, Pediatric, Population Based Studies, Prognosis, Prognostic Factors, Prognostics, Solid Cancers, Solid Carcinomas, Survival, Tumors, White Blood Cell Count.

This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2006, Pain & Central Nervous System Week via NewsRx.com.