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URL http://www.rockymountainbmt.com/news/Different-gammadelta-T-clones-sustain-GVM-and-GVH-effects-after-non-myeloablative-transplantation-971.html

Different gamma/delta T clones sustain GVM and GVH effects after non-myeloablative transplantation

06-06-2006

In multiple myeloma patients, different gamma/delta T clones sustain GVM and GVH effects after non-myeloablative transplantation.

"TCR gamma/delta profiles were analyzed in 13 multiple myeloma patients after allogeneic non-myeloablative transplantation. Results show that both aGVHD and minimal residual disease (MRD) eradication did significantly affect TCR gamma/delta profile," scientists in Italy reported.

"During follow-up, 6 patients developed an aGVHD episode; in 5 of them, this event fitted with a modification of the TCR profile. Eleven patients achieved PCR-negativity during follow-up. In the 90% of them, the appearance of a new predominant TCR peak was concomitant to the disappearance of the IgH clone," explained S. Galimberti and colleagues, University of Pisa.

The researchers concluded, "These results suggest that different T gamma/delta populations would sustain GVM and GVH effects after non-myeloablative allogeneic transplant."

Galimberti and colleagues published their study in Leukemia Research (Different gamma/delta T clones sustain GVM and GVH effects in multiple myeloma patients after non-myeloablative transplantation. Leuk Res, 2006;30(5):529-535).

For additional information, contact S. Galimberti, University of Pisa, Ospedale S Chiara, Sect Hematology, Dept. Oncology Transplant & Advances Med, Via Roma 56, I-56100 Pisa, Italy.

The publisher's contact information for the journal Leukemia Research is: Pergamon-Elsevier Science Ltd., the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England.

Keywords: Pisa, Italy, Gamma/Delta T Cells, Leukemia, Multiple Myeloma, Non-Myeloablative Allogeneic Transplant, Oncology.

This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2006, Clinical Oncology Week via NewsRx.com.