Findings from University of Oslo, Biotechnology Center advance knowledge in waldenstrom macroglobulinemia

01-26-2007

Researchers detail in "The amino acid sequence of an AL-protein, AL-KH, isolated from the heart of a patient with Waldenstroms macroglobulinemia and amyloidosis," new data in waldenstrom macroglobulinemia. According to recent research from Oslo, Norway, "An AL-protein was isolated from the myocardium of a patient (KH) with Waldenstrom's macroglobulinemia. SDS-PAGE of the fraction revealed three major bands ranging from 14 to 30 kDa."

"Two of the major bands showed a positive PAS test for carbohydrate. The amino acid sequence was established for positions 1-92 and for positions 104-205, except for 150-187," wrote S. Kjaeraas and colleagues, University of Oslo, Biotechnology Center.

The researchers concluded: "According to the data, the AL-protein KH is derived from the kappa 1c germline gene."

Kjaeraas and colleagues published their study in Amyloid (The amino acid sequence of an AL-protein, AL-KH, isolated from the heart of a patient with Waldenstroms macroglobulinemia and amyloidosis. Amyloid, 2006;13(4):260-2).

For additional information, contact S. Kjaeraas, University of Oslo, Dept. of Biochemistry, Biotechnology Centre of Oslo, Oslo, Norway.

Publisher contact information for the journal Amyloid is: Parthenon Publishing Group, Richmond House, White Cross, South Road, Lancaster LA1 4XQ, England.

Keywords: Norway, Oslo, Biotechnology, Waldenstrom Macroglobulinemia.

This article was prepared by Science Letter editors from staff and other reports. Copyright 2007, Science Letter via NewsRx.com.