Lymphoma and leukemia diagnosed by endoscopic ultrasound-guided fine-needle aspiration biopsy

07-06-2006

Deep-seated lymphoma and leukemia could be diagnosed or staged with endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB).

"We retrospectively studied the use of EUS-FNAB as a tool for the diagnosis of deep-seated lymphoma. An on-site assessment at the time of EUS-FNAB was performed by a cytopathologist using Diff-Quik (American Scientific Products, McGraw Park, IL) stain," scientists in the United States reported.

"In addition, Papanicolaou stains were performed on EUS-FNAB smears, immunohistochemical stains were performed on cell blocks, and additional samples were sent for flow cytometric analysis. Final cytologic diagnosis was correlated with surgical pathology and/or clinical follow-up. We evaluated EUS-FNAB specimens of deep-seated lymph nodes, spleen, stomach, and pancreas, and 1 EUS-guided needle core biopsy specimen of a lymph node. Thirteen cases of deep-seated lymphoma were diagnosed, including non-Hodgkin lymphomas and Hodgkin lymphoma. One case of hairy cell leukemia was diagnosed," explained J.L. Pugh and colleagues, University of Alabama.

The researchers concluded, "EUS-FNAB is a minimally invasive, cost-effective, and useful tool for the primary diagnosis or staging of deep-seated lymphomas."

Pugh and colleagues published their study in American Journal of Clinical Pathology (Diagnosis of deep-seated lymphoma and leukemia by endoscopic ultrasound-guided fine-needle aspiration biopsy. Am J Clin Pathol, 2006;125(5):703-709).

For additional information, contact D.N. Jhala, University of Alabama, Dept. Surgery Pathology, Division Cytopathol, Kracke Bldg, Room 532A, 619 19th St. S, Birmingham, AL 35233, USA.

The publisher's contact information for the American Journal of Clinical Pathology is: American Society Clinical Pathology, 2100 W Harrison St., Chicago, IL 60612, USA.

Keywords: Birmingham, Alabama, United States, Deep-seated Leukemia, Deep Seated Lymphoma, Diagnosis, Diagnostics, Endoscopic Fine Needle Aspiration, Endoscopy, Oncology, Women's Health.

This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2006, Clinical Oncology Week via NewsRx.com.