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URL http://www.rockymountainbmt.com/news/Myeloid-hematopoietic-stem-cells-with-minimal-lymphopoietic-potential-may-be-the-acute-myeloid-leukemia-transformation-site-4481.html

Myeloid hematopoietic stem cells with minimal lymphopoietic potential may be the acute myeloid leukemia transformation site

09-13-2006

"The transformation site in acute myeloid leukemia (AML) has been proposed to be pluripotent hematopoietic stem cells (PHSCs), and the lymphoid development of leukemic PHSCs may be suppressed by leukemogenic event.

"Recent data from multiple laboratories have contradicted the current hierarchical model of hematopoiesis and indicated the presence of myeloid HSCs with minimal lymphopoietic potential (MyHSCs) in mice," scientists in Japan report.

According to C. Satoh and colleagues at Nippon Medical College in Tokyo, "Based on these findings and re-evaluating the published data on AML stem cells, we hypothesize that MyHSCs may be the transformation site in AML."

"If so, therapy targeting leukemic MyHSCs but sparing PHSCs is worth investigating," investigators suggested.

Satoh and colleagues published their study in Leukemia Research (Hypothesis: Myeloid-restricted hematopoietic stem cells with self-renewal capacity may be the transformation site in acute myeloid leukemia. Leuk Res, 2006;30(4):491-495).

For additional information, contact K. Ogata, Nippon Medical College, Dept. Internal Medicine 3, Division Hematology, Bunkyo Ku, 1-1-5 Sendagi, Tokyo 1138603, Japan.

The publisher's contact information for the journal Leukemia Research is: Pergamon-Elsevier Science Ltd., the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England.

This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2006, Clinical Oncology Week via NewsRx.com.