Stem cell apheresis prediction method generates accurate and immediate yield predictions

10-09-2006

A stem cell apheresis prediction method generates accurate and immediate yield predictions.

According to a study from Italy, "Stem cell collection is a standard procedure for the procurement of autologous grafts to rescue myelosuppression induced by high-dose treatments. Accurate prediction of collection yields may contribute to optimize planning and quality control of collection.

"Data of 313 autologous hematopoietic stem cell (AHSC) evaluable collections performed in 208 patients with hematologic and nonhematologic neoplasms from seven centers were prospectively analyzed to test the accuracy of yield predictions generated by a formula that required the input of peripheral blood (PB) CD34+ cell precount and desired PB volume to be processed."

"Data were matched in a standard linear regression, in a zero-point regression analysis and tested for prediction accuracy. Further 165 AHSC collections were analyzed on a single-centre basis, using yield predictions as reference standards," wrote L. Pierelli and colleagues at ASL Viterbo.

"Analysis showed high levels of correlation between measured collection yields (my) and predictions (py) (R=0.85; p=0.000000) as well as high degree of prediction accuracy (my vs. py at paired t-test: p=0.114781; median my/py ratio=1.23).

"Analysis of additional 165 AHSC collections on a single-center basis showed that the analyzed centers had 70% or more measured yields comprising the 0.6-1.8 interval of the my/py ratio. The observance of the 'efficiency' my/py interval assured collection quality control in these centers confirming the reliability of the method," reported scientists.

The authors concluded, "This prediction method generates accurate and immediate yield predictions allowing collection planning and rapid efficiency control.

"As a consequence of our study, four centers out of seven use the described method to plan both leukapheresis number and single-procedure blood processing volume while the remaining three centers plan leukapheresis number on the basis of our predictions, maintaining a fixed single-procedure 200 ml/kg blood volume processing, according to their centre AHSC collection policy."

Pierelli and colleagues published the results of their research in Vox Sanguinis (Accurate prediction of autologous stem cell apheresis yields using a double variable-dependent method assures systematic efficiency control of continuous flow collection procedures. Vox Sang, 2006;91(2):126-134).

For additional information, contact L. Pierelli, ASL Viterbo, Osped Belcolle, Service Immunoematol & Trasfus, Strada Sammartinese, I-01100 Viterbo, Italy.

The publisher of the journal Vox Sanguinis can be contacted at: Blackwell Publishing, 9600 Garsington Rd., Oxford OX4 2DQ, Oxon, England.

Keywords: Viterbo, Italy, Collection Efficiency, Leukapheresis, Quality Control, Stem Cell Collection, Yield Prediction.

This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2006, Clinical Oncology Week via NewsRx.com.