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T cells are suppressed in a mediated fashion in B-cell non-Hodgkin lymphoma

06-28-2006

Recent research from the United States has reported on intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma (NHL).

"Most NHLs are of B-cell origin, but the tumor tissue can be variably infiltrated with T cells. In the present study, we have identified a subset of CD4+CD25+ T cells with high levels of CTLA-4 and Foxp3 (intratumoral T-reg cells) that are overrepresented in biopsy specimens of B-cell NHL (median of 17% in lymphoma biopsies, 12% in inflammatory tonsil, and 6% in tumor-free lymph nodes; p=.001)," wrote Z.Z. Yang and colleagues, Mayo Clinic & Mayo Foundation.

"We found that these CD4+CD25+ T cells suppressed the proliferation and cytokine (IFN-gamma and IL-4) production of infiltrating CD4+CD25- T cells in response to PHA stimulation. PD-1 was found to be constitutively and exclusively expressed on a subset of infiltrating CD4+CD25- T cells, and B7-H1 could be induced on intratumoral CD4+CD25+ T cells in B-cell NHL.

"Anti-B7-H1 antibody or PD-1 fusion protein partly restored the proliferation of infiltrating CD4+CD25- cells when cocultured with intratumoral T-reg cells. Finally, we found that CCL22 secreted by lymphoma B cells is involved in the chemotaxis and migration of intratumoral T-reg cells that express CCR4, but not CCR8," reported the authors.

The researchers concluded, "Taken together, our results suggest that Treg cells are highly represented in the area of B-cell NHL and that malignant B cells are involved in the recruitment of these cells into the area of lymphoma."

Yang and colleagues published their study in Blood (Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma. Blood, 2006;107(9):3639-3646).

For more information, contact S.M. Ansell, Mayo Clinic & Mayo Foundation, Division of Hematology & Internal Medicine, 200 1st St. SW, Rochester, MN 55905, USA.

Publisher contact information for the journal Blood is: American Society of Hematology, 1900 M Street. NW Suite 200, Washington, DC 20036, USA.

Keywords: Rochester, Minnesota, United States, B-Cell Non-Hodgkin Lymphoma, CDC T Cells, Cell Suppression.

This article was prepared by Cancer Weekly editors from staff and other reports. Copyright 2006, Cancer Weekly via NewsRx.com.