Trakya University, Department of Hematology publishes research in lymphoma

03-12-2007

Data detailed in "Increased adiponectin level in non-Hodgkin lymphoma and its relationship with interleukin-10. Correlation with clinical features and outcome" have been presented. According to recent research published in the Journal of Experimental & Clinical Cancer Research, "It was reported that interleukin-10 (IL-10) level increased in non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL) patients; moreover this was associated with poor prognosis. In addition, it was stated that adiponectin induced the antiinflammatory cytokine IL-10."

"We evaluated adiponectin and IL-10 levels in NHL and CLL patients. We included newly diagnosed 28 NHL, 23 CLL patients, and 17 healthy subjects. In NHL patients, adiponectin level was higher than in CLL group and controls (p values <0.05). In CLL group, IL-10 level was lower than in NHL, and control groups (p values <0.05). Adiponectin level had a positive correlation with IL-10 level in the NHL patients (r=0.41, p=0.04). In the NHL group, the median survival of patients with high IL-10 levels was shorter (22 months vs. not reached, p=0.03). Increased IL-10 levels helped to predict poor outcome in our NHL patients," wrote G.E. Pamuk and colleagues, Trakya University, Department of Hematology.

The researchers concluded: "High adiponectin levels and a relationship between adiponectin/IL-10 in newly diagnosed NHL patients might suggest a role for both in the immunodysregulation in NHL."

Pamuk and colleagues published their study in the Journal of Experimental & Clinical Cancer Research (Increased adiponectin level in non-Hodgkin lymphoma and its relationship with interleukin-10. Correlation with clinical features and outcome. Journal of Experimental & Clinical Cancer Research, 2006;25(4):537-41).

For additional information, contact G.E. Pamuk, Trakya University Medical Faculty, Dept. of Hematology, Edirne, Turkey.

The publisher's contact information for the Journal of Experimental & Clinical Cancer Research is: Apsit Association PROM Stud Immunology Tumor, Viale Regina Elena 291, 00161 Rome, Italy.

Keywords: Turkey, Edirne, Cancer Research, Hematology, Lymphoma, Oncology.

This article was prepared by Hematology Week editors from staff and other reports. Copyright 2007, Hematology Week via NewsRx.com.